Interaction between HIV/AIDS and Substance Abuse

New HIV-transmission rates attributable to injection drug use and to heterosexual activity with an infected partner (who often times is a drug user) continue to remain high in New Haven and Connecticut (HIV/AIDS Surveillance Report,  Connecticut Department of Public Health, 1999).  The strong connection between HIV transmission and substance abuse is not surprising when considering that substance abusers are more likely to engage in high risk behaviors such as sharing (contaminated) injection equipment, or participating in unprotected intercourse with a familiar or an unfamiliar partner. Because of the strong link between HIV transmission and substance abuse, it is useful to understand the prevalence of substance use and abuse in New Haven.


Prevalence of HIV/AIDS in the Injection Drug Use (IDU) Population:

Greater New Haven continues to be severely impacted by HIV infection.  New Haven has also seen the shifting of the AIDS epidemic from Men who have Sex with Men (MSM) to Injecting Drug Users (IDUs) and MSM/IDUs. According to recent (12/8/99) epidemiological data issued from the Connecticut Department of Public Health AIDS Epidemiology Unit, 58.9 % of diagnosed AIDS cases have been IDUs and MSM/IDUs.  During 1998, IDU minorities accounted for 63.8% of cases (40.3% were African American and 23.5% Hispanic) and 36.5% of Caucasian derivation.  Women accounted for 29.3% of AIDS cases and continue to represent a significant number of cases, including heterosexual transmission and as a consequence of IDU.  IDU and heterosexual contact, particularly among non-injection drug-using women who are sexual partners with male IDUs also continue to account for a high rate of increase of new AIDS cases.

HIV disease has been established as one of the most costly and complex diseases to care for in the health care system.  This cost and complexity has increased dramatically with patients’ maintenance on protease inhibitors and anti-retroviral protocols that typically include 3 to 6 medications requiring multiple daily doses.  While the task of providing basic care to HIV infected individuals--especially those with a history of substance abuse--is clearly very challenging, co- morbid features (including medical problems, psychiatric problems, and social problems) in individual patients can make this task even more difficult.  For example, patients with a history of substance abuse and HIV are also at risk for tuberculosis, hepatitis, bacterial infections, sexually transmitted diseases, certain cancers, and trauma.  All of these conditions have complex management regimens of their own, some of which may interact with HIV therapies, and methadone interacts with protease inhibitors in ways that require added monitoring.  In addition, this population is at high risk for psychiatric disease including depression, anxiety, and personality disorder--each of which can interfere with patients’ cognitive functioning and judgment.  Basic HIV care, on the other hand, requires rather sophisticated cognitive abilities.


APT Research Studies  Related to HIV/AIDS

In addition to HIV testing and counseling at The APT Foundation treatment clinics, the Foundation offers a specialized methadone maintenance programs at the Orchard Hill Clinic and Legion Clinic.  The APT Foundation, in collaboration with Yale University’s School of Medicine, sponsors a number of research studies that relate to HIV/AIDS, and to reducing HIV risk behavior.  The studies are listed below and are funded under grants from the National Institute for Drug Addiction (NIDA)

  • Reducing High Risk Behavior in HIV-Positive Drug Abusers, S. Kelly Avants, Ph.D., Principal Investigator  

  • Reducing HIV Risk in Methadone Maintained Patients, S. Kelly Avants, Ph.D., Principal Investigator

  • HIV and Cocaine Use: Cardiovascular Effects and Therapy, Arthur Margolin, Ph.D., Principal Investigator

  • Optimizing Auricular Acupuncture for HIV+ Drug Abusers, Arthur Margolin, Ph.D., Principal Investigator

  • Counseling Conditions for Thrice Weekly BUP in a PCC, Richard Schottenfeld, MD, Principal Investigator


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